There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer
There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that: 1. The endometrium in stimulated cycles is not optimal for implantation 2. Pregnancy rates are increased following FET 3. Perinatal outcomes are less affected after FET 4. Preimplantation genetic screening We will follow only natural and modified natural cycles patients. Spontaneous ovulation will documented with hormonal and sonographic monitoring. Hormonal monitoring are including estradiol and luteinizing hormone (LH). Sonographic monitoring is including follicule diameter (16-20 mm). At modified natural cycles we will use hCG triggering for ovulation approximately 16-20 mm diameter. We will compare success rate between natural and modified natural cycles
Study Type
OBSERVATIONAL
Enrollment
100
When follicle is ready for ovulation, we will use this injection by intra-dermal route
we will use that drug in the natural modified transfer group after embryo transfer
we will do transfer when the endometrium is ready
Acibadem MAA University Atakent Hospital
Istanbul, Turkey (Türkiye)
birth
live birth
Time frame: bigger than 24 weeks pregnancy
pregnancy rate
hcg blood test
Time frame: 10th day after embryo transfer
clinical pregnancy rate
positive fetal cardiac activity
Time frame: 8 weeks
abortion rate
abortion after visualization of fetal cardiac activity
Time frame: 8 weeks
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