The Expression Heparanase in Term and Preterm Placentas

Hillel Yaffe Medical Center20 enrolled

Overview

Heparanase is an endo-β-glucuronidase that cleaves heparin-sulfate (HS) side chains of heparan sulfate proteoglycans, an integral constituent of the extra cellular matrix (ECM). This study aims to investigate the association between heparanase expression in the human placenta and preterm birth (PTB) . The investigators hypothesize that an abnormal placentation causes relative placental ischemia that induces higher rates of heparanase expression.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Preterm Birth

Interventions

Placental analysisOTHER

Analysis of placenta to determine expression of heparanase

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Singleton pregnancy Exclusion Criteria: * High-risk patients * Multiple pregnancy * Significant maternal illness * Significant fetal anomaly

Locations (1)

Hille Yaffe Medical Center

Hadera, Israel

Outcomes

Primary Outcomes

Heparanase expression

Heparanase expression in the human placenta following delivery will be evaluated by western blot analysis in the three groups and will be compared to determine differences in the levels.

Time frame: Six months

Data from ClinicalTrials.gov

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