Exercise and Overnight Motor Sequence Task

The University of Hong Kong51 enrolled

Overview

The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Schizophrenia and Related Disorders Psychotic Disorders

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged from 18 to 55 * Based on the SCID diagnosed to have schizophrenia and related psychotic disorders * Ability to understand the nature of the study and to give written informed consent Exclusion Criteria: * Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise may be contraindicated), and seizure disorders * Comorbid substance dependence * Unstable psychotic symptoms * A history of brain trauma or organic brain disease * Known history of intellectual disability or special school attendance * Answered one or more "yes" in the PAR-Q and without doctors approval for exercise

Outcomes

Primary Outcomes

The sleep-dependent procedural memory consolidation after 12 weeks of intervention

Tested by comparing the finger-tapping motor sequence task performance between the three groups during the 12-week follow-up assessment.

Time frame: 12-week Follow-up

Secondary Outcomes

The verbal memory consolidation after 12 weeks of intervention

Tested by comparing the logical memory task performance between the three groups during the 12-week follow-up assessment

Time frame: 12-week Follow-up

The attention performance after 12 weeks of intervention

Measured by using the cancellation task performance and compare between the three groups during the 12-week follow-up assessment

Time frame: 12-week Follow-up

The sleep quality after 12 weeks of intervention

Measured by using the Pittsburgh Sleep Quality Index (PSQI) and compare the differences between the three groups during the 12-week follow-up assessment

Time frame: 12-week Follow-up

The insomnia severity after 12 weeks of intervention

Measured by using the Insomnia Severity Index (ISI) and compare the differences between the three groups during the 12-week follow-up assessment

Time frame: 12-week Follow-up