Study of 18F-DCFPyL PET/CT Imaging in Patients With Prostate Cancer

Inclusion Criteria: * Histological confirmation of prostate cancer * Patients receiving androgen deprivation treatment (ADT) with GnRH analogs, GnRH antagonists or bilateral orchiectomy of any duration. * Cohort A: nmCRPC (status post- primary treatment with radical prostatectomy, radiation of any type or both) * Negative 99mTc-methylene diphosphonate bone scan and CT of the chest abdomen and pelvis within 6 weeks of 18F-DCFPyL PET/CT * Treatment with ADT with or without a second line novel AR targeted treatment (abiraterone, enzalutamide, or both) or 4 weeks after discontinuation of first generation antiandrogen (bicalutamide , flutamide, nilutamide- one or more permitted) for ≥ 12 months. * Rising PSA ≥ 10 ng/ml (confirmed by 2 determinations one week apart) * PSADT ≤ 9 months * Cohort B: mCRPC * Treatment with ADT with or without abiraterone and or enzalutamide or both for ≥ 6 months and/or 4 weeks after discontinuation of first generation antiandrogen (bicalutamide , flutamide, nilutamide- one or more permitted). * PSA ≥ 2.0 ng/ml confirmed X 1 week apart, any PSADT * Patients enrolled in other clinical trials are eligible if they satisfy all other criteria of eligibility. * No new therapeutic interventions planned or scheduled to be instituted prior to the course of this study both on cohorts A and B before conventional radiologic progression is evidenced. * Patients or their legal representatives must have the ability to read, understand and provide written informed consent for the initiation of any study related procedures. Exclusion Criteria: * Patient will be excluded from enrollment if he had a radioisotope within 5 physical half-lives prior to PET imaging