Plasma exchange procedures remove procoagulant and anticoagulant factors. Every procedure increases the risk of bleeding and repeated procedures increase the risk of bleeding mostly because lower fibrinogen levels. The aim of study is to define coagulation status of patient after plasmapheresis with different laboratory tests and to investigate the possibility of fibrinogen concentrate replacement for the correction of induced coagulation disorder.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
20
Haemocomplettan will be infused after plasma exchange procedure
Fresh frozen plasma will be part of replacement fluid
University Medical Centre Ljubljana
Ljubljana, Gorenjska, Slovenia
RECRUITINGEffect of plasmapheresis replacement fluid type on fibrinogen level
Change of fibrinogen level after plasmapheresis treatment depending on replacement fluid type
Time frame: Right after every plasmapheresis session, during the whole plasmapheresis treatment (usually about 2 weeks)]
Effect on coagulation tests after plasmapheresis - ROTEM EXTEM
ROTEM (EXTEM MCF) change after plasmapheresis treatment depending on replacement fluid type
Time frame: Right after every plasmapheresis session, during the whole plasmapheresis treatment (usually about 2 weeks)]
Effect on coagulation tests after plasmapheresis - ROTEM FIBTEM
ROTEM (FIBTEM MCF) change after plasmapheresis treatment depending on replacement fluid type
Time frame: Right after every plasmapheresis session, during the whole plasmapheresis treatment (usually about 2 weeks)]
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.