Coronary chronic total occlusions (CTOs) are defined as an occluded coronary vessel with TIMI defined as an occluded coronary vessel with TIMI (Thrombolysis in Myocardial Infarction) grade flow 0 and an estimated duration of at least 3 months. They are frequently encountered in patients undergoing coronary angiography. The application of contemporary techniques and the use of advanced dedicated equipment lead to high procedural success and low adverse events rates in experienced centers. Fractional flow reserve (FFR) is a validated tool to assess physiological severity of coronary artery disease and have a prognostic role after percutaneous coronary intervention (PCI). SPECT (Single-Photon Emission Computed Tomography) is the golden standard for detection of myocardial ischemia. Recanalization of a CTO leads to a number of anatomical and pathophysiological changes to the coronary circulation. These include anatomical and functional collateral vessels regression and significant lumen enlargement because of recovery of blood flow and restoration of vasomotor tone. The effect of PCI on CTO is unknown. The aim of this study was to assess the functional result of CTO PCI by measuring FFR and D SPECT before and immediately post-CTO PCI and at short-term follow-up.
Coronary chronic total occlusions (CTOs) are defined as an occluded coronary vessel with TIMI defined as an occluded coronary vessel with TIMI (Thrombolysis in Myocardial Infarction) grade flow 0 and an estimated duration of at least 3 months. They are frequently encountered in patients undergoing coronary angiography. The application of contemporary techniques and the use of advanced dedicated equipment lead to high procedural success and low adverse events rates in experienced centers. Fractional flow reserve (FFR) is a validated tool to assess physiological severity of coronary artery disease and have a prognostic role after percutaneous coronary intervention (PCI). SPECT (Single-Photon Emission Computed Tomography) is the golden standard for detection of myocardial ischemia. Recanalization of a CTO leads to a number of anatomical and pathophysiological changes to the coronary circulation. These include anatomical and functional collateral vessels regression and significant lumen enlargement because of recovery of blood flow and restoration of vasomotor tone. The effect of PCI on CTO is unknown. The aim of this study was to assess the functional result of CTO PCI by measuring FFR and D SPECT before and immediately post-CTO PCI and at short-term follow-up.
Study Type
OBSERVATIONAL
Enrollment
150
fractional flow reserve and SPECT detection
Zhongshan Hospital
Shanghai, Shanghai Municipality, China
score of Seattle angina questionnaire
the result of Seattle angina questionnaire
Time frame: one year
socre of Self-Rating Anxiety Scale
result of socre of Self-Rating Anxiety Scale
Time frame: one year
socre of EuroQol five dimensions questionnaire
result of EuroQol five dimensions questionnaire
Time frame: one year
Composite of cardiac death, target vessel myocardial infarction and target lesion revascularization record in follow-up
Composite of cardiac death, target vessel myocardial infarction and target lesion revascularization record in follow-up
Time frame: one year
the success rate of Percutaneous Coronary Intervention
the success rate of Percutaneous Coronary Intervention
Time frame: one year
rate of cardiac death rate
rate of cardiac death rate in one year recorded in follow-up
Time frame: one year
rate of target vessel revascularization rate
rate of target vessel revascularization rate in one year recorded in follow-up
Time frame: one year
rate of recurrent myocardial infarction rate
rate of recurrent myocardial infarction rate in one year recorded in follow-up
Time frame: one year
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