The main objective of this study is to analyze a new noninvasive imaging examination, OCT angiography, in the evaluation of neovascular remodeling and early signs of recurrence of wet AMD undergoing treatment on OCTA and to correlate OCTA findings with SD-OCT findings.
Study Type
OBSERVATIONAL
Enrollment
49
Hôpital Pellegrin, CHU de Bordeaux
Bordeaux, France
CHI de Créteil
Créteil, France
Hôpital La Croix Rousse
Lyon, France
Hôpital Lariboisière, APHP
Paris, France
Centre Ophtalmologique d'Imagerie et de Laser,
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 13
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 13
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 13
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 13
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 13
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 13
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 13
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 13
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Paris, France
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 13
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 13
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: baseline
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 1
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 2
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 3
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 4
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 5
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 6
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 7
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 8
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 9
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 10
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 11
presence of flow on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 12
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: baseline
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month1
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 2
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 3
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 4
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 5
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 6
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 7
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 8
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 9
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 10
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 11
presence of collaterals on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 12
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: baseline
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 1
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 2
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 3
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 4
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 5
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 6
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 7
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 8
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 9
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 10
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 11
presence of peripheral arcade on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 12
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 1
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 2
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 3
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 4
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 5
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 6
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 7
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 8
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 9
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 10
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 11
presence of arteriolization on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 12
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: baseline
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 1
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 2
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 3
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 4
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 5
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 6
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 7
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 8
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 9
presence of vascular loops on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 10
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: baseline
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 1
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 2
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 3
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 4
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 5
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 6
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 7
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 8
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 9
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 10
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 11
presence of dark halo on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 12
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: baseline
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 1
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 2
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 3
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 4
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 5
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 6
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 7
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 8
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 9
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 10
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 11
presence of feeder vessel on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 12
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: baseline
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 1
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 2
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 3
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 4
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 5
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 6
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 7
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 8
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 9
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 10
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 11
presence of flow void on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 12
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: baseline
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 1
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 2
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 3
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 4
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 5
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 6
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 7
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 8
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 9
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 10
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 11
measure of neovascular area on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 12
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: baseline
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 1
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 2
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 3
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 4
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 5
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 6
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 7
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 8
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 9
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 10
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 11
measure of neovascular density on OCTA
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time
Time frame: at month 12
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 13
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at baseline
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 1
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 2
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 3
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 4
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 5
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 6
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 7
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 8
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 9
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 10
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 11
Intraretinal and/or subretinal fluid in SD-OCT
Time frame: at month 12
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at baseline
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 1
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 2
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 3
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 4
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 5
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 6
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 7
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 8
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 9
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 10
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 11
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 12
visual acuity in logmar
Measure of best-corrected visual acuity (BCVA) measured on ETDRS
Time frame: at month 13
presence or abscence of hemorrhage, fibrosis and atrophy on fundus color photography
Time frame: at 1 months
presence or abscence of hemorrhage on fundus color photography
Time frame: at 1 months
presence or abscence of fibrosis on fundus color photography
Time frame: at 1 months
presence or abscence of atrophy on fundus color photography
Time frame: at 1 months
presence or abscence of hemorrhage on fundus color photography
Time frame: at 13 months
presence or abscence of fibrosis on fundus color photography
Time frame: at 13 months
presence or abscence of atrophy on fundus color photography
Time frame: at 13 months
type of choroidal neovascularization on fluorescein angiography (type 1, type 2 or mixed lesions)
Time frame: Baseline
type of choroidal neovascularization on fluorescein angiography (type 1, type 2 or mixed lesions)
Time frame: at month 13
type of choroidal neovascularization on indocyanine green angiography (type 1, type 2 or mixed lesions)
Time frame: baseline
type of choroidal neovascularization on indocyanine green angiography (type 1, type 2 or mixed lesions)
Time frame: at month 13
choroidal thickness on EDI-OCT
Time frame: monthly during 13 months
type of choroidal neovascularization on SD-OCT (type 1, type 2 or mixed lesions)
Time frame: monthly during 13 months