Through multicenter, prospective, randomized, controlled clinical studies comparing different treatment options (fertility-sparing surgery and ovarian preservation surgery and radical surgery)therapeutic efficacy, safety and quality of life of patients, exploration of the best strategies and risks for the treatment of early endometrial cancer, and promotion and application.
Patients eligible for enrollment are selected and divided into three groups randomly, including fertility group,ovarian preservation group and endometrial cancer radical surgery group. Take interventions including fertility preservation surgery,ovarian preservation surgery and endometrial cancer radical surgery for patients in different groups respectively. Compare therapeutic efficacy, safety and quality of life of patients to evaluate three treatment and explore the best treatment for clinical application.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
170
Take hysterectomy and bilateral adnexectomy.
Take endometrectomy , preserve uterus and bilateral ovaries.
Take hysterectomy,preserve bilateral ovaries.
Shengjing Hospitaol of China Medical University
Shenyang, Liaoning, China
Total survival Time
calculate the time from patients enter the group to death
Time frame: 6 months
the change of Ovarian volume
measure the ovarian volume dynamically by ultrasonography
Time frame: 6 months, 1 year, 2 years, 3 years, 4 years, 5 years
the change of endocrine function evaluation
measure the endocrine function(hormone level) dynamically by blood detection
Time frame: 6 months, 1 year, 2 years, 3 years, 4 years, 5 years
Progression Free Survival
calculate the time from patients enter the group to tumor progression
Time frame: 6 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.