Comparative Analysis of Serum Lipid Profiles in Patients With and Without Gallstones

Services Hospital, Lahore100 enrolled

Overview

Gallbladder disease is one of the most common diseases of the gastrointestinal tract. Various studies have shown an association between gallstones and an alteration in the serum lipids. The objective of this study will be to compare serum lipid profile of gallstone patients with the controls.

This prospective cross-sectional study will be conducted in the Surgical Department of the Services Institute of Medical Sciences. A total of 50 patients will beincluded in the study after screening through the inclusion criteria. A control group of 50 inpatients with no personal or family history of gallstones will be also recruited for comparison. Results will be expressed as mean with standard deviation. Students t- test will be used to compare the data between the patients and the control groups (p\<0.05 will be considered statistically significant). SPSS software, version 20 will be used for statistical analysis.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Gallstone Dyslipidemias

Interventions

Serum lipid profileDIAGNOSTIC_TEST

Blood samples drawn from the patients and controls will be analyzed for serum cholesterol, serum triglycerides, serum LDLs and serum HDL levels. All the results will be recorded on a performa

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female patients with the gall stone disease * Age from 20 to 70 years * Gallstones were diagnosed through the ultrasound Exclusion Criteria: * Patients with acalculous gallbladder disease on ultrasound, * Patients with terminal ileal resection, * Patients with hemolytic diseases (hereditary spherocytosis, sickle cell anemia on history and CBC film), * Patients with liver cirrhosis (on abdominal ultrasound) and * Patients on antihyperlipidemic drugs

Locations (1)

Services hospital

Lahore, Punjab Province, Pakistan

Outcomes

Primary Outcomes

serum cholesterol levels

serum cholesterol levels of patients and case group will be compared with Students t- test was (p\<0.05 will be considered statistically significant)

Time frame: 1 week

serum triglyceride levels

serum triglyceride levels of gallstone patients and control group will be compared via student t-test (p\<0.05 was considered statistically significant)

Time frame: 1 week

serum HDL levels

serum HDL levels of patients and contoled will be compared with student t-test (p\<0.05 was considered statistically significant)

Time frame: 1 week

serum LDL leves

serum LDL leves of patients and control will be compared through student t-test (p\<0.05 was considered statistically significant)

Time frame: 1 week

Data from ClinicalTrials.gov

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