The present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral BDNF level and mitochondrial function of individuals with MCI. It is hypothesized that: 1) the combined physical-cognitive training program will be superior to the physical and cognitive training program alone; and 2) the degree of cognitive improvement will be positively correlated with the improvement of plasma BDNF and mitochondrial function.
Recent research suggests that the benefits of combined physical-cognitive training may be greater than either physical or cognitive training alone. Nevertheless, this synergistic effect has been demonstrated mainly in cognitively intact older adults. Studies examining the effects of combined physical-cognitive training in older adults with MCI are scarce and show mixed results. Moreover, few studies have determined the effects of the combined training on peripheral brain-derived neurotrophic factor (BDNF) and mitochondrial function. Thus, the present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral BDNF level and mitochondrial function of individuals with MCI. The present study will provide insight into the interplay among the training program, peripheral BDNF concentration, mitochondrial function, and cognitive function. Importantly, the findings will have clinical implication regarding the training program that is feasible and effective in improving cognitive function of older adults with MCI which ultimately will have great impact on public health as this population is at high risk of progression to AD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
128
combined physical-cognitive training
Multi-component physical exercise
cognitive training
Faculty of Associated Medical Sciences, Chiang Mai University
Chiang Mai, Thailand
change from baseline Alzheimer's Disease Assessment- cognitive subscale at 3 months
Alzheimer's Disease Assessment-cognitive subscale will be assessed at baseline and 3 months. The total scores range from 0-70, with higher scores (≥ 18) indicating greater cognitive impairment.
Time frame: 3 months
change from baseline Rey auditory verbal learning score at 3 months
Memory will be assessed using Rey auditory verbal learning test.
Time frame: 3 months
change from baseline Trail Making B-A score at 3 months
Executive function will be assessed using Trail Making Test part B-A.
Time frame: 3 months
change from baseline brain-derived neurotrophic factor level at 3 months
Level of plasma brain-derived neurotrophic factor (BDNF) will be determined.
Time frame: 3 months
change from baseline Digit Span score at 3 months
Attention will be assessed using Digit Span forward-backward test.
Time frame: 3 months
change from baseline stepping response time at 3 months
Processing speed will be measured using stepping response time.
Time frame: 3 months
change from baseline time to complete Timed Up and Go at 3 months
Functional ability will be assessed using time to complete Timed Up and Go (TUG).
Time frame: 3 months
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change from baseline physiological profile assessment score at 3 months
Fall risk will be assessed using the physiological profile assessment. The test consists of five sensorimotor and balance measures including visual contrast sensitivity, proprioception, quadriceps muscle strength, hand reaction time, and postural sway. The five PPA components are weighted to compute a composite z-score distribution with high scores indicating increased fall risk.
Time frame: 3 months
change from baseline cellular oxidative stress level at 3 months
Mitochondrial function will be determined from cellular oxidative stress level
Time frame: 3 months