To establish the sensory profile of patients using quantitative sensory testing (QST) and questionnaires as well as the level of sensitisation using temporal summation and diffuse noxious inhibitory control paradigms in all patients undergoing a chronic pain intervention at Barts Health NHS Trust. Primary objective- To identify the phenotype of responders and non-responders to a chronic pain intervention using QST sensory profile as well as the sensitisation paradigms. Secondary objective- To establish the correlation between sensory profile, and sensitisation parameters as well as other measures of chronic pain as per Initiative on Methods, Measurement and Pain Assessment in clinical trials (IMMPACT) recommendation. Common interventions performed at Barts Health NHS Trust includes Neuromodulation, targeted epidural steroid and/or radiofrequency treatment, 8% Capsaicin patch and pharmacological interventions such as anti-neuropathic agent and opioids.
Study Type
OBSERVATIONAL
Enrollment
10
Quantitative sensory testing
Dr Theresa Wodehouse
London, Essex, United Kingdom
• To identify the phenotype of responders and non-responders to a chronic pain intervention using QST sensory profile as well as the sensitisation paradigms.
This is assessed by comparing and reporting any change in QST results before and after the intervention.
Time frame: QST changes at 4 weeks is taken as primary objective.
• To establish the correlation between sensory profile and sensitisation parameters as well as other measures of chronic pain as per Initiative on Methods, Measurement and Pain Assessment in clinical trials (IMMPACT) recommendation •
QST changes
Time frame: 2 weeks 3, 6 months and one year
The effect on functionality and quality of life following chronic pain intervention
QST changes
Time frame: 2 weeks and 3, 6 months and 1 year.
Whether central sensitisation can be used as a bedside biomarker to predict outcome after interventions for chronic pain (i.e. the more centrally sensitised the more superior improvement from treatment)
QST changes
Time frame: 2 weeks and 3, 6 months and 1 year
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