Isomaltulose VS Sucrose - Postprandial Effect on Incretin Profile and Second Meal Effect

German Institute of Human Nutrition50 enrolled

Overview

This study evaluates the different postprandial effect of isomaltulose and sucrose on the incretin profile and as an determinant for the second meal effect. In this nutritional intervention study, healthy participants and T2DM patients ingest 2 standardized meals for breakfast and lunch in combination with either sucrose or palatinose on 2 separate days. In addition, blood samples are taken to analyze markers of the carbohydrate metabolism, incretins and specific inflammation markers.

Isomaltulose is a natural occurring disaccharide with a similar structure to sucrose. It is composed of glucose and fructose, but is linked by an α-1,6-glycosidic bond instead of α-1,2. Due to its binding, isomaltulose is slowly hydrolysed, which results in a rather weak postprandial glycemic-insulinemic response, accompanied by a minimal GIP secretion and a stimulated secretion of GLP-1. In addition, several studies have shown that the intake of foods with a low glycemic index, such as isomaltulose, tend to improve the metabolic reaction to a subsequent meal. As the exact mechanism of this "second meal effect" is still unknown, the investigators hypothesize that the modified release and action of GIP and GLP-1 are key players in regard to the described effects.Therefore, isomaltulose could be a suitable tool for reducing the risk of developing diabetes, obesity and CVD as well as improve blood glucose control in people with diabetes. In summary, this study evaluates the different postprandial effect of isomaltulose and sucrose on the incretin profile and as a determinant for the second meal effect. In this nutritional intervention study, healthy participants and T2DM patients ingest 2 standardized meals for breakfast and lunch in combination with either sucrose or palatinose on 2 separated days. In addition, blood samples are taken to analyze markers of the carbohydrate metabolism, incretins and specific inflammation markers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Diabetes Mellitus, Type 2 Metabolic Syndrome

Interventions

Intervention ADIETARY_SUPPLEMENT

Intervention BDIETARY_SUPPLEMENT

Intervention CDIETARY_SUPPLEMENT

Intervention DDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 45 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * for T2DM patients: insulin-independent * for healthy subjects: at least 1 component of the metabolic syndrom: * Body mass index (BMI) ≥ 30 kg/m² * Waist-hip ratio (WHR) ≥ 85 for women and ≥ 90 for men * hypertension * dyslipidemia * glucose / insulin intolerance Exclusion Criteria: * medications: intake of medications which influence glucose metabolism * alcohol / drug abuse * physical diseases: endocrinological, malign, serious cardiovascular diseases * acute / chronic communicable disease * psychic diseases

Locations (1)

German Institute of Human Nutrition

Potsdam, Brandenburg, Germany

Outcomes

Primary Outcomes

disposition index

Alteration of the Insulin secretion due to the intake of isomaltulose or sucrose in combination with different times and meal compositions. This should lead to an improved beta-cell response (Insulin secretion)