Comparison of Scalp Microbiota of the Psoriasis and Seborrheic Dermatitis Patients

Istanbul Medeniyet University30 enrolled

Overview

A sterile swap specimen taken from the scalp of the patients with psoriasis vulgaris or seborrheic dermatitis and the volunteer control group will be examined in our study. The examples of the microbiota of the patients will be taken both the lesional scalp and the lesion-free part of the scalp. Then, the microbiota differences between the lesioned scalp and the lesion-free scalp of both groups, and the microbiome differences between the two groups and the control group will be evaluated.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Psoriasis Vulgaris Seborrheic Dermatitis Microbial Colonization

Interventions

MicrobiotaOTHER

The scalp microbiota

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients with scalp psoriasis 2. Patients with seborrheic dermatitis 3. Agree to participate in research 4 - Do not use any drugs for their disease topically or systemically for two months Exclusion Criteria: 1. Patients who do not want to participate in the study 2. Patients with psoriasis vulgaris or seborrheic dermatitis that does not effect scalp. 3. Those with chronic diseases that may affect skin microbiome 4. Patients using antibiotics, antifungal or antiviral therapy for any reason for the last one month. 5. Patients who are using topical or systemic drugs for their illness

Outcomes

Primary Outcomes

The scalp microbiota of the patients with psoriasis and seborrheic dermatitis

The aim of this study is to compare the scalp microbiota of psoriasis vulgaris and seborrheic dermatitis both the lesion and lesion-free parts and also the control group and to assess their role on etiopathogenesis. Determining the microbiota of this region which is frequently involved and resistant to treatment may change the treatment approach. In addition, scalp microbiome of seborrheic dermatitis may be a causal factor of rapid relapse after treatment. The similarities between the microbiota of the psoriasis vulgaris and seborrheic dermatitis cases with only scalp involvement can guide us not only for the diagnosis but also the treatment. There are a few reports about the role of Malassezia subgroups in the pathogenesis, but it is known that there are many different flora members on the scalp. Exposing these can change both our diagnosis and treatment options.

Time frame: 6 months

Secondary Outcomes

The differences between the scalp microbiota of different countries

Does the microbiota of the patients change between the countries? To our knowledge, there is no similar studies in present. Presenting the scalp microbiome of Turkish population can be a start to understand whether there is a difference in terms of the countries.