This is a two-part study to determine the relative bioavailability of two different prototype capsules of GDC-0134 to that of an existing reference capsule of GDC-0134 under both fed and fasted conditions. The study is open to healthy female participants of non-childbearing potential.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
38
Participants will receive a single oral dose of GDC-0134 reference capsule F09.
Participants will receive a single oral dose of GDC-0134 prototype capsule F15.
Participants will receive a single oral dose of GDC-0134 prototype capsule F16.
Covance Research Unit - Daytona
Daytona Beach, Florida, United States
Covance Research Unit - Dallas
Dallas, Texas, United States
Maximum Observed Concentration (Cmax) of GDC-0134.
Time frame: The time points at which the outcome measure was assessed were 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 48, 96, 144, 336, 504 hours post-dose.
Area Under the Curve Extrapolated to Infinity (AUCinf) of GDC-0134
Time frame: The time points at which the outcome measure was assessed were 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 48, 96, 144, 336, 504 hours post-dose.
Percentage of Participants With Adverse Events (AEs)
Time frame: From baseline through the end of study (approximately 11 weeks)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.