Couples referred for microdissection-TESE (m-TESE) due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed retrieval of testicular spermatozoa by conventional techniques with needle or TruCut are included. The women are stimulated with FSH in IVF protocols and the aspirated oocytes vitrified with usual applied techniques. Fresh sperm retrieved by micro-TESE are used for fertilization of the warmed oocytes. when it is not possible to obtain testicular sperm, the couples are offered fertilization with warmed oocytes. Fertilization, cleavage, implantation and pregnancy rates using sperm from the patients versus from sperm donors will be compared.
Study Type
OBSERVATIONAL
Enrollment
100
Centre of Andrology & Fertility Clinic, Department D, Odense University Hospital
Odense, Denmark
Centre of Andrology & Fertility Clinic, Odense University Hospital
Odense, Denmark
RECRUITINGCleavage rate
Measurement of % of cleavage among the warmed oocytes
Time frame: six years
Pregnancy rate
Measurement of serum-hCG and ultrasonography at gestation age week 7
Time frame: six years
Fertilization rate
Measurement of % of fertilization among the warmed oocytes
Time frame: six years
Implantation rate
Measurement of the % of transferred embryos implanting into the uterus
Time frame: six years
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