The Use Of Domperidone For The Relief Of Refractory Upper Gastrointestinal GI Symptoms

Inclusion Criteria: 1. Males or females who are 18 years of age or older 2. Symptoms or manifestations secondary to Gastro esophageal reflux disease (GERD) (e.g., persistent esophagitis, heartburn, upper airway signs or symptoms or respiratory symptoms), gastrointestinal motility disorders such as nausea, vomiting, severe dyspepsia or severe chronic constipation that are refractory to standard therapy. Exclusion Criteria: 1. i. History of, or current, arrhythmias including ventricular tachycardia, ventricular fibrillation and Torsade des Pointes. Patients with minor forms of ectopy (PACs) are not necessarily excluded. ii. Clinically significant bradycardia, sinus node dysfunction, or heart block. iii. Prolonged QTc (QTc\>450 milliseconds for males, QTc\>470 milliseconds for females) iv. Clinically significant electrolyte disorders. 2. Gastrointestinal hemorrhage or obstruction. 3. Presence of a prolactinoma (prolactin-releasing pituitary tumor). 4. Pregnant or breast feedings female. 5. Known allergy to domperidone