In this single-center study the investigators will analyze gender differences among patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years. About 11 000 patients will be included. Patient data including fluid therapy will be drawn from the electronic medical record; Take Care and Clinisoft. In the logistic regression analysis, the investigators will adjust for age, gender, comorbidities, vital signs, preliminary focus of infection, level of care and renal replacement therapy. The aim is to analyze gender differences in fluid treatment and the response to fluid treatment and if the treatment is associated with differences in mortality.
Study Type
OBSERVATIONAL
Enrollment
5,000
Södersjukhuset
Stockholm, Stockholm County, Sweden
Gender differences in fluid treatment
Millilitres of fluid given per kilogram of patient weight (ml/kg).
Time frame: Fluid therapy during the first six hours (adherence to sepsis bundles) and the first five days after admission.
Association between amount of fluid and mortality
Analyze the whole cohort and female/ male gender as subgroups
Time frame: In-Hospital Mortality, 30- and 90-days mortality
Type of fluids
Type according to Anatomical, Therapeutic and Chemical Classification System
Time frame: First five days after admission.
Association between fluid therapy and levels of lactat
Analyze the whole cohort and female/ male gender as subgroups
Time frame: First five days efter admission
Association between fluid therapy and need for/ dose of vasopressors/inotropic drugs
Analyze the whole cohort and female/ male gender as subgroups
Time frame: First five days efter admission
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