This study evaluates the efficacy of Long-acting Somastostatin analogs as treatment for type I gastric neuroendocrine tumors.
Study Type
OBSERVATIONAL
Enrollment
30
Patients will receive 6-12 monthly injections every 28 (+/- 3) days.
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
RECRUITINGRecurrence rate
Time frame: 1 year
Change in clinical symptoms
Measured by a questionnaire, including whether the patient presents with dyspepsia, abdominal pain, cramps, bloating, nausea, vomiting, lack of appetite, facial flushing.
Time frame: 6 months to 1 year
Concentration of serum Gastrin
Concentration of serum Gastrin after 12 hours of fasting
Time frame: 6 months to 1 year
Enterochromaffin-like cell (ECL) status
Normal Hyperplasia: ECL cell proliferation with a diameter \<150 μm, distinguished in: normal pattern/simple hyperplasia, linear, micronodular and adenomatoid hyperplasia. Dysplasia: ECL cell proliferation \>150 but \<500 μm. Type I gastric carcinoid: ECL proliferation \>500 μm.
Time frame: 6 months to 1 year
Presence of side-effects of Octreotide
Measured by a questionnaire for patients and clinician's report. Including: hypersensitivity, endocrine disorders (abnormal thyroid functions), metabolism and nutrition disorders (abnormal blood glucose), headache, bradycardia or tachycardia, dyspnea, gastrointestinal disorders (diarrhea, abdominal pain, nausea, constipation, flatulence), hepatobiliary disorders, skin disorders, injection site reaction.
Time frame: 6 months to 1 year
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