Cannabis is one of the widely used psychoactive substances in the world. With increasing legalization, the prevalence of driving under the influence of cannabis will undoubtedly rise. At present, roadside detection of cannabis intoxication is largely dependent on drug recognition experts who rely on changes in eye movements when impaired. In this regard, use of eye trackers can help to detect impairment in drivers. The purpose of the present study is to determine the feasibility of the use of eye trackers in detecting impairment in participants who smoked a cannabis cigarette.
Participants will attend one study session after determination of eligibility. During this session, they will smoke a cannabis cigarette with 12.5% THC prior to driving a simulator. Driving will be assessed prior to smoking cannabis and at 7 time points after smoking cannabis. Eye tracking measures will also be taken while driving after smoking cannabis. Blood will be drawn for determination of levels of the psychoactive substance THC and its metabolites. Saliva tests, urine tests and subjective tests will also be performed at various times points after smoking cannabis.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SCREENING
Masking
NONE
Enrollment
10
750 mg cannabis cigarette with 12.5% THC
Center for Addiction and Mental Health
Toronto, Ontario, Canada
Change in eye gaze
Measures of eye movement with an eye tracker
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in saccades
Measures of quick eye movements with an eye tracker
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in eye fixations
Measure of where the eye is looking with an eye tracker
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in blinking rate
The number of blinks, measured with an eye tracker
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in blinking duration
The length of time that blinks last, measured with a eye tracker
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in blinking speed
How fast the blinking is, measured with an eye tracker
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in pupil size
The diameter of pupils while driving, measured with an eye tracker
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in mean speed on the driving simulator
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The speed, in km, while driving a driving simulator
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in standard deviation of speed on the driving simulator
The amount of variation in speed while driving the driving simulator
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in maximum speed on the driving simulator
The greatest speed obtained on the driving simulator
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in standard deviation of lateral position on the driving simulator
The amount of weaving while driving the driving simulator
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in minimum time to collision on the driving simulator
The time needed to collide with the car in front, while driving the simulator
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in number of collisions
The number of times a car impacts another car while driving the simulator
Time frame: baseline, 15 minutes, 35 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in blood concentrations of delta-9-tetrahydrocannabinol
The levels of the psychoactive component of cannabis, THC, in blood
Time frame: baseline, 5 minutes, 25 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in blood concentrations of carboxy-tetrahydrocannabinol
The levels of the inactive metabolite of THC in blood
Time frame: baseline, 5 minutes, 25 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in blood concentrations of 11-hydroxy-tetrahydrocannabinol
The levels of the active metabolite of THC in blood
Time frame: baseline, 5 minutes, 25 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in saliva THC detection
Detection of THC in saliva
Time frame: baseline, 5 minutes, 25 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in systolic blood pressure
Vital signs
Time frame: baseline, 5 minutes, 25 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in diastolic blood pressure
Vital signs
Time frame: baseline, 5 minutes, 25 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in heart rate
Vital signs
Time frame: baseline, 5 minutes, 25 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in temperature
Vital signs
Time frame: baseline, 5 minutes, 25 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in number of respirations per minute
Vital signs
Time frame: baseline, 5 minutes, 25 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours
Change in Subjective cannabis effects with a visual analog scale
The amount of liking of cannabis from 0 to 100, with 100 being the greatest value
Time frame: baseline, 5 minutes, 25 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours