This study evaluates the effect of a combination of glycirrhizic acid, Cinnamomun Zeylanicum and corosolic acid for the treatment of metabolic syndrome. Participants receive the supplement or a placebo.
The supplement is composed by of a combination of glycirrhizic acid, Cinnamomun Zeylanicum and corosolic acid. They act in different way reducing insulin resistance, which is the main cause of metabolic syndrome. It was a randomized, controlled study involving 60 women with the metabolic syndrome following the criteria proposed by ATP III in 2015. Main outcomes were the improvement of the parameters that characterizes the metabolic syndrome, such as glucose and insulin levels, triglycerides, HDL-cholesterol and blood pressure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
glycyrrhizic acid 38 mg + Cinnamomum Zeylanicum 150 mg + corosolic acid 480 mcg 2 pills per day
Changes in glycemia
Reduction of glycemia (mg/dl)
Time frame: 3 months
Changes in HDL-cholesterol
Increase of HDL-C (mg/dl)
Time frame: 3 months
changes in HOMA-IR
measured as the ratio between glycaemia (mg/dl) and insulin (UI)
Time frame: 3 months
changes in total-cholesterol
reduction of cholesterol (mg/dl)
Time frame: 3 months
changes in triglycerides
reduction in triglycerides (mg/dl)
Time frame: 3 months
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