The PKUBC-T is a prospective cohort study carried out in Tongzhou district of Beijing, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to 6 years old. Biological samples including blood and tissue samples are also collected from mothers and their children.
Maternal and child health is of great concern globally. Early life phase of a fetus and infant is a critical period for the development of health and disease in the whole life. Exposure of negative environmental, nutritional and lifestyle factors in pregnant women during this period can have adverse effects on fetal and infant. In addition, for mothers, complications during pregnancy could also have a negative effect on long-term health of mothers, such as diabetes, hypertension. Thus, the Peking University Birth Cohort in Tongzhou is primarily aimed to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to 6 years old. Biological samples including blood and tissue samples are also collected from mothers and their children.
Study Type
OBSERVATIONAL
Enrollment
5,426
This is an observational study without any intervention
Peking University
Beijing, Beijing Municipality, China
Numbers of participants with pregnancy complications
Including gestational diabetes, gestational hypertension, anemia, and hypothyroidism during pregnancy
Time frame: At delivery
Numbers of participants with adverse pregnancy outcomes
Including preterm birth, low birth weight, macrosomia, abortion, stillbirth, and birth defects.
Time frame: At delivery
Weight in kilogram changes during childhood
Measured by health professionals in clinic
Time frame: At birth and age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years
Height in centimeter changes during childhood
Measured by health professionals in clinic
Time frame: At birth and age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years
Early Child development 1
Measured by Ages\&Stages Questionnaires (ASQ).There are 6 questions in each of 5 domains of development: communication, gross motor, fine motor, problem-solving skills, and adaptive skills. Each question is given a 10 (yes), 5 (sometimes), or 0 (not yet) score according to the parents' answers. The sum scores (range from 0 to 300) and scores for each domain (range from 0 to 60) are calculated. Chinese norms are available for each domain, and any domain screened \<2 SDs below the mean is considered a positive screening. A higher ASQ score means better development.
Time frame: Age at 6 weeks and 3 years
Early Child development 2
Measured by Denver Developmental Screening Test (DDST). DDST comprises 125 test items grouped into four domains of child development: 25 personal-social (PS), 29 fine motor (FM), 39 language (LA) and 32 gross motor (GM). These test items are administered using a bell, glass bottle, set of 10 blocks, rattle, pencil, tennis ball, yarn, raisins, cup, white doll, white paper, and baby bottle. A child's raw score on each test item is marked as tested pass, failure, refusal, or no opportunity. The result of the test is labeled as "normal," "suspect" or "abnormal". Normal development means that there is no delay or at the maximum one warning. Abnormal development means that there is one or more than one delay situation. Suspicious development means that it is a situation involving one delay, one delay and one warning or two or more than two warnings. The number of children with normal, suspect or abnormal development is calculated.
Time frame: Age at 8-12 months
Incidence of diabetes mellitus in women
Measured by health professionals in clinic
Time frame: 6 weeks after delivery and 3 years after delivery
Incidence of hypertension in women
Measured by health professionals in clinic
Time frame: 6 weeks after delivery and 3 years after delivery
Incidence of child overweight and obesity
Measured by health professionals in clinic
Time frame: Age at 6 weeks, 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years
The proportion of children with warning signs
Measured by warning signs screening
Time frame: Age at 3 months, 6 months, 8 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 6 years
Fetal Biparietal Diameter
Measured by health professionals in clinic with ultrasound
Time frame: At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week.
Fetal Head Circumference
Measured by health professionals in clinic with ultrasound
Time frame: At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week.
Fetal Abdominal Circumference
Measured by health professionals in clinic with ultrasound
Time frame: At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week.
Fetal Femur Length
Measured by health professionals in clinic with ultrasound
Time frame: At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week.
Fetal Humerus Length
Measured by health professionals in clinic with ultrasound
Time frame: At 20-24 gestational week, 30-32 gestational week and 37-41 gestational week.
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