Overweight, physically inactive but otherwise healthy adults habitually eating a traditional Western diet will follow an ad libitum self-administered Paleo diet for 8-weeks. Blood and body composition will be measured before and after the intervention period.
The Paleo diet is a dietary method that is gaining popularity among the general population due to potential weight loss and disease prevention benefits. The feasibility of the Paleo diet and the effectiveness of self-administration in improving cardiometabolic disease risk factors remains uncertain. Examination od cardiometabolic disease risk factors in overweight, physically inactive adults before and after 8-weeks of an ad libitum self-administered Paleo dietary intervention. Methods: Overweight, physically inactive but otherwise healthy adults habitually eating a traditional Western diet follow an ad libitum self-administered Paleo diet for 8-weeks. Blood samples were analyzed for fasting cardiometabolic disease biomarkers. Participants complete three-day dietary recalls prior to, and during weeks 4 and 8 of the intervention to confirm Western diet consumption at pre-, track compliance, and to assess dietary changes.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
21
Participants provided with a brochure providing a thorough description of the diet, \~8 example recipes for each meal (i.e. breakfast, lunch, dinner, and snacks) included as a sample menu, and guidance to assist in shopping and self-preparation of food for the prescribed diet and to improve adherence. Diet consisted of following the popular "paleolithic" diet
Chatham University
Pittsburgh, Pennsylvania, United States
University of Houston
Houston, Texas, United States
Serum cytokines
Serum measurement of interleukin (IL)-4 (pg/dL), IL-10 (pg/dL), interferon (INF)-gamma (pg/dL), tumor necrosis factor (TNF; pg/dL)
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
Serum growth factor
Serum measurement of brain derived neurotrophic factor (BDNF; ng/mL)
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
Serum biomarkers of energy homeostasis
Serum fibroblast growth factor (FGF)-21 (pg/mL) and adiponectin (pg/mL)
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
Serum glucose metabolism biomarkers
leptin (mg/dL), glucagon-like peptide (GLP)-1 (mg/dL), resistin (mg/dL), insulin (mg/dL), Gastric inhibitory polypeptide (GIP; mg/dL), glucagon (mg/dL), visfatin (mg/dL), ghrelin (mg/dL), plasminogen activator inhibitor (PAI)-1 (mg/dL), C-peptide (mg/dL)
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
Serum adipokines
Serum omentin (ng/mL) and nesfatin (ng/mL)
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
Waist and hip circumference
Circumference of two midsection areas of the body (waist and hip) to estimate central adiposity
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
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Subcutaneous body fat
Skin fold thickness (mm) of body fat
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
Dietary composition
3-day food diary to approximate macronutrient composition (grams)
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
Dietary energy intake
3-day food diary to approximate total energy intake (kcal)
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
Blood pressure
Measurement of blood pressure from the arm (mmHg)
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
Body weight
Measurement of participant's body weight (kg)
Time frame: Change from pre-intervention (week zero) and post-intervention (upon completion of week 8)
Body height
Measurement of participant's height (m) to (along with body weight) calculate body mass index (kg/m\^2)
Time frame: pre-intervention (week zero)