Diabetes Research on Patient Stratification

Study 1 Inclusion criteria * No treatment with insulin-sensitising, glucose-lowering or other antidiabetic drugs * Fasting capillary blood glucose \<10 mmol/l at baseline * White European (self-report of parental ethnicity) * Age ≥35 and \<75 years Exclusion criteria * Diagnosed diabetes of any type, HbA1c ≥6.5% (48 mmol/mol) or fasting plasma glucose ≥7.0 mmol/l or 2 h plasma glucose \>11.0 mmol/l previously * For women, pregnancy, lactation or plans to conceive within the study period * Use of a pacemaker * Any other significant medical reason for exclusion as determined by the investigator Study 2 Inclusion Criteria: * Patients diagnosed with type 2 diabetes not less than 6 months and not more than 24 months before baseline examination * Management by lifestyle with or without metformin therapy * All HbA1c \<7.6% (\<60 mmol/mol) within previous 3 months * White European * Age ≥35 and \<75 * Estimated GFR \>50 ml/min' Exclusion Criteria: * Type 1 diabetes * A previous HbA1c \>9.0% (\>75 mmol/mol) * Prior treatment with insulin or an oral hypoglycaemic agent other than metformin * BMI \<20 or \>50 kg/m2 * Pregnancy, lactation or plans to conceive within the study period * Any other significant medical reason for exclusion as determined by the investigator