What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)?

Murdoch Childrens Research Institute380 enrolled

Overview

This is a multicentre prospective audit to determine the incidence of immunodeficiency in children with IPD. Aims and/or research question of the project 1. To determine the incidence of primary immunodeficiency in children \>2 years who present with IPD 2. To determine the types of immunodeficiency associated with IPD in children

Study Type

OBSERVATIONAL

Enrollment

380

Conditions

Invasive Pneumococcal Disease, Recurrent Isolated, 1 Invasive Pneumococcal Disease, Recurrent Isolated, 2 Invasive Pneumococcal Disease, Protection Against Primary Immunodeficiency

Interventions

Eligibility

Sex: ALLMin age: 0 MonthsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Children aged 0 to 18 years admitted to one of the six centres with IPD. Exclusion Criteria: * Children who do not fulfil the age criteria for immunological evaluation at that particular site e.g. aged \<2 years at Royal Children's Hospital. * Children with a known underlying condition predisposing to IPD i.e. nephrotic syndrome.

Locations (6)

Sydney Children's Hospital

Sydney, New South Wales, Australia

Adelaide Women's and Children's Hospital

Adelaide, South Australia, Australia

Monash Health

Clayton, Victoria, Australia

Royal Children's Hospital

Melbourne, Victoria, Australia

Lady Cilento Children's Hospital

Brisbane, Australia

Capital and Coast District Health Board

Wellington, New Zealand

Outcomes

Primary Outcomes

incidence of primary immunodeficiency in children who present with invasive pneumococcal disease

This will be picked up upon prospective immunological testing, after identification of patients with invasive pneumococcal disease. A series of tests will be performed depending on the clinical opinion of the immunology team. Such tests may include lymphocyte subsets, complement function, serum immunoglobulin levels, memory B cells, vaccine antibody responses, etc.

Time frame: 3 years

types of immunodeficiency associated with children who present with invasive pneumococcal disease

This will be determined based on the testing performed by the immunologists.

Time frame: 3 years

Secondary Outcomes

whether increased referrals of children who present with invasive pneumococcal disease for investigation of primary immunodeficiency facilitates early detection

This information will come from reviewing the case series of patients who are identified from this study. The incidence of those with primary immunodeficiency will be analysed against known background rates of diagnoses.

Time frame: 3 years

Data from ClinicalTrials.gov

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