Effect of Dexmedetomidine and Propofol on Regional Cerebral Tissue Oxygen Saturation

Ain Shams University50 enrolled

Overview

50 patients divided into 2 groups .Group I Dexmedetomidine infusion. Group II with Propofol infusion

: 50 patients anticipated for open heart surgeries were encompassed in the study. Patients were divided into 2 groups, group P (receiving propofol) and group D (receiving dexmedetomidine) during CPB. Both groups were studied for variations in right and left rScO2 as well as postoperative cognitive dysfunction using the Mini Mental State Examination Score (MMSE) test.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Regional Cerebral Tissue Oxygen Saturation

Interventions

Dexmedetomidine Hydrochloride 0.1 MG/MLDRUG

Dexmedetomidine Hydrochloride 0.1 MG/ML infusion at 0.2-0.7 mcg/kg/min

Propofol 10 MG/MLDRUG

Propofol 10 MG/ML infusion at 0.3 -4 mg/kg/h

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing valve surgeries * Patients undergoing on pump coronary artery bypass grafting surgeries Exclusion Criteria: * emergency cases, patients with cervical spine pathology (cervical stenosis, cervical disc herniation, carotid stenosis), patients with cerebral pathology (cerebral strokes, ischemic attacks), patients with Mini Mental State Examination Score (MMSE) of 23 or less, complicated cases with prolongation of the cardiopulmonary bypass period, patients needing moderate hypothermia

Locations (1)

Ain Shams Cardiothoracic hospital

Cairo, Egypt

Outcomes

Primary Outcomes

cognitive function assessment

Mini Mental State Examination Score (MMSE) test to assess orientation to time and place with ability to speak, think and draw. with highest ability 32 and lowest o

Time frame: 24 hours postoperative

Data from ClinicalTrials.gov

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