Co-administration of propofol and remifentanil is considered to be an ideal total intravenous anesthesia technique, which is widely used in induction and maintenance of general anesthesia. Remifentanil and propofol can be mixed in polypropylene syringes for one hour with a remaining concentration of 91% in small concentrations of remifentanil. However, delivery of remifentanil-propofol mixture by target-controlled infusion(TCI) for general anesthesia in surgical procedure has not been described. Breast cancer surgery ( including modified radical mastectomy and breast-conserving surgery) is a less time-consuming procedure for patients with breast cancer with one-hour duration in our hospital. This pilot study was to examine the merit of remifentanil-propofol mixture as a GA regimen for breast cancer surgery.
Previous studies has described the feasibility and safety of remifentanil-propofol mixture use in sedation of pediatric patients undergoing magnetic resonance imaging or flexible fiberoptic bronchoscopy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
84
Participants receive total intravenous anesthesia with remifentanil-propofol mixture by single TCI pump in intervention group. All TCI target concentration adjustments or extra bolus of propofol or remifentanil during operation were based on BIS and ANI monitor.
Tri-Service General hospital
Taipei, Taiwan
Frequency of TCI device adjustments
Total times of TCI pump adjustment
Time frame: during procedure
Mean blood pressure
measured by non-invasive blood pressure cuff
Time frame: at 5 minute intervals perioperatively throughout the procedure in an average of 60 minutes
Heart rate
recorded by ECG and pulse oximetry
Time frame: at 5 minute intervals perioperatively throughout the procedure in an average of 60 minutes
Patient satisfaction
Rating of satisfaction by questionnaire
Time frame: the 1 day after operation
postoperative analgesia rescue
Analgesics use during PACU stay
Time frame: An average of 30 minutes after arriving at PACU
Total dose of remifentanil
total consumption of remifentanil during procedure
Time frame: At the end of surgery
Total dose of propofol
total consumption of propofol during procedure
Time frame: At the end of surgery
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