Effects of Coffee Consumption on Health Among Adults

Zhejiang University156 enrolled

Overview

The purpose of this study is to research the changes of typical thermal processing food intervention on health outcome, metabolites, and gut microbiota, in order to explore the molecular mechanism of interaction between maillard reaction associated hazards and complex food matrix, and provide scientific basis and reference model for combining food nutrition and safety protection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

156

Conditions

Health

Interventions

Warm WaterOTHER

300 mL Warm Water per day for 8 weeks

Caffeinated CoffeeOTHER

300 mL Caffeinated Coffee per day for 8 weeks

Decaffeinated CoffeeOTHER

300 mL Decaffeinated Coffee per day for 8 weeks

Eligibility

Sex: ALLMin age: 17 YearsMax age: 29 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Non-smoking, non-occupational exposed healthy volunteers, 18.5\<BMI\<30 kg/m\^2, were screened. If the evaluation of disease history, blood biochemistry and blood routine was normal, the volunteers were considered healthy. Exclusion Criteria: * The main exclusion criteria included people with high exposure to cold and fever, recent drug intake (including dietary supplement intake), alcohol intake, vegetarians, pregnancy, high-temperature processed meat and beverages such as coffee and milk tea.

Locations (1)

Zhejiang university

Hangzhou, China

Outcomes

Primary Outcomes

Change in blood glucose from baseline

Time frame: 8 weeks

Change in blood lipids from baseline

Time frame: 8 weeks

Secondary Outcomes

Urinary biomarkers levels of acrylamide, furans, and furfuryl alcohol

Urinary levels of environmental pollutants (e.g., acrylamide, furans, and furfuryl alcohol), measured using liquid chromatography-mass spectrometry (LC-MS)

Time frame: 8 weeks; 24 hours

Change of metabolites

Time frame: 8 weeks

Change in gut microbiota

Time frame: 8 weeks

Data from ClinicalTrials.gov

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