Pharmacogenomics and Pharmacometabolomics of Acamprosate Treatment Outcome

Inclusion Criteria: 1. Age 18 to85; DSM-5 diagnosis of AUD determined by PRISM; 2. Completion of alcohol detoxification (CIWA score \< 5) and no alcohol for at least 7 days (but no more than 35 days); 3. Ability to provide informed consent 4. Ability to speak English 5. Willingness to use the study medications for 3 months and attend follow-up visits. 6. No chronic/daily use of benzodiazepines, opioids, or stimulants for a period of time which is determined by 3 x the medication half-life value (see addendum A) to be completed before the initiation of study medication (acamprosate or placebo). 7. Willingness to discontinue previously prescribed acamprosate for a period of at least 3 days before randomization to study medication (acamprosate or placebo). Exclusion Criteria: 1. Hypersensitivity or allergy to acamprosate 2. Current use of wellbutrin and not willing to switch to an acceptable antidepressant medication 3. Renal impairment (creatinine level \>1.5 mg/dL); 4. Diagnosis of advanced liver disease indicated in the medical record or by a MELD score of above 10; 5. Women who are pregnant, breastfeeding, or planning to become pregnant during the next year; 6. Primary diagnosis of substance use disorder other than alcohol as determined by PRISM or in medical record review or secondary diagnosis of active (within the past year) benzo/sedative dependence, opioid dependence, stimulant dependence, heroin dependence, and/or cocaine dependence 7. Refusal to abstain from any chronic/daily use of prescribed benzodiazepines, opioids, stimulants, cannabis related medication such as CBD or medical marijuana, during the course of participation. 8. Current use of Naltrexone and not willing to stop and switch to Acamprosate/Placebo 9. Current use of Antabuse. 10. Active suicidal ideation or any unstable medical or psychiatric condition as determined by responses to PRISM or by the investigator. 11. Status of involuntary or court-ordered admission at time of consent.