Respiratory Drive in Patients With Univentricular Congenital Heart Disease

University Hospital, Montpellier32 enrolled

Overview

The aim is to evaluate the correlation between the respiratory control to hypercapnia at rest and the VE/VCO2 slope measured during cardiopulmonary exercise testing. The hypothesis is that patient with univentricular congenital heart disease have a increasing of respiratory drive like chronic heart failure. This increasing of respiratory drive could participate in the increasing of VE/VCO2 slope measured during cardiopulmonary exercise testing and in the genese of central apnea index during the sleep.

The patients with univentricular congenital heart disease will perform : * a cardiopulmonary exercise testing with measure VE/VCO2 slope, * a measure of the respiratory drive to hypercapnia with occlusion pressure during the rebreathing with at rest (P0,1/PetCO2). * A polysomnography with a scoring of central apnea index. Correlation will be evaluate between P 0,1/PetCO2 with VE/VCO2 slope and between P0,1/PetCO2 central apnea index.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Univentricular Heart Children, Adult

Interventions

polysomnographyPROCEDURE

Sleep examination strictly non-invasive with skin sensors. This exploration would allow for the detection of respiratory sleep disorders and consider of appropriate management for patients.

Eligibility

Sex: ALLMin age: 8 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Functionally univentricular congenital heart disease * Age ≥ 8 years * Consent of the adult patient or the parents or legal guardians of the minor patient. * Beneficiary of the social security scheme Exclusion Criteria: * Size \<120 cm (minimum size for the stress test) * Medical contraindication to exercise test or presence of : myocardial infarction less than 3 months old, unstable angina, uncontrolled severe arrhythmias, symptomatic aortic stenosis, uncontrolled heart failure, pulmonary embolism, evolutionary phlebitis, pericarditis, myocarditis, progressive endocarditis, aortic dissection * Unstable patient with severe intellectual disability or complex pathology making polysomnography impossible * Pregnant woman

Locations (2)

Arnaud de Villeneuve - University Hospital Pediatric and Congenital Cardiology Department Regional Reference Center - M3C

Montpellier, Occitanie, France

Institut Saint-Pierre

Palavas-les-Flots, France

Outcomes

Primary Outcomes

Pearson correlation - The measure the respiratory drive to hypercapnia with P0.1 during the rebreathing technique at rest

between the measure the respiratory drive to hypercapnia with P0.1 during the rebreathing technique at rest \- between VE/VCO2 slope during a cardiopulmonary exercise

Time frame: day 90 after inclusion visit (visit 2)

Secondary Outcomes

Pearson correlation

* between the measure of the respiratory drive to hypercapnia with P0.1, the rebreathing technique at rest and Central apnea index scored with a polysomnography during a night * between the measure of the respiratory drive to hypercapnia with P0.1, the rebreathing technique at rest and NYHA, New York Heart Association Functional Classification * between the measure of the respiratory drive to hypercapnia with P0.1, the rebreathing technique at rest and the quality of life evaluated by questionary * between the measure of the respiratory drive to hypercapnia with P0.1, the rebreathing technique at rest and data of cardiac echography

Time frame: day 90 after inclusion visit (visit 2)

Data from ClinicalTrials.gov

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