Alcohol is a major public health problem and its neurotoxic effects are, among other things, responsible for altering the functioning of cerebral neurotransmission pathways. The retina is an anatomical and developmental extension of the central nervous system. It is composed of several layers of retinal neurons that share similar anatomical and functional properties with brain neurons. Retinal neurons are notably equipped with a complex system of neurotransmission constituted by the main neurotransmitters that are involved in the central effects of alcohol: glutamate, dopamine, serotonin ... The retina is used here as a site of indirect investigation for abnormal central neurotransmission pathways following regular alcohol use. It is recognized to date as a good site for investigating central abnormalities in neuropsychiatric and addictive disorders. The objective of this project is to study the retinal function using electroretinogram (ERG) in regular alcohol users to isolate potential markers of cerebral neurotransmission abnormalities.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
60
we measured the waves a, b, oscillatory potentials, back ground noise and i for the flash ERG, the waves P50 and N95 for the pattern ERG and the P1, N1 and N2 for the multifocal ERG
Centre Psychothérapique de Nancy
Laxou, Nancy, France
modification of amplitude
measured with flash electroretinogram and pattern electroretinogram / amplitude in microvolt
Time frame: Day 0 (=day of inclusion = the only visit of the study)
modification of implicite time parameters
measured with flash electroretinogram and pattern electroretinogram - implicite time in millisecond
Time frame: Day 0 (=day of inclusion = the only visit of the study)
modification of amplitude of the oscillatory potential
waves P1, P2, P3, P4 measured with flash electroretinogram - amplitude in microvolt
Time frame: Day 0 (=day of inclusion = the only visit of the study)
modification of implicit time of the oscillatory potential
waves P1, P2, P3, P4 measured with flash electroretinogram - implicite time in millisecond
Time frame: Day 0 (=day of inclusion = the only visit of the study)
modification of amplitude of the background noise
measured with the flash electroretinogram, flicker 3.0 sequence - amplitude in microvolt
Time frame: Day 0 (=day of inclusion = the only visit of the study)
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