This study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation (iTBS), a type of repetitive transcranial magnetic stimulation and (ii) determine how APT + iTBS changes the neurocognitive system of attention in individuals with persistent attention deficits related to mTBI +/- PTSD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
200
Intermittent Theta Burst Stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation (rTMS), which uses short magnetic field pulses applied to the scalp to induce currents in the underlying brain. iTBS will be delivered with the Magventure MagProX100 with MagOption stimulator and Magpro Cool Coil B65 A/P. The Magpro Cool Coil B65 A/P can be switched to active or placebo (A/P).
APT-III is an attention processing training program
computerized cognitive training
Northwestern University
Chicago, Illinois, United States
RECRUITINGMoody Neurorehabilitation Institute
Houston, Texas, United States
RECRUITINGChange in the Mayo Portland Adaptability Inventory (MPAI)
Self-reported ability, adjustment and community participation. It is comprised of 30 items and three subscales: Ability Index, Adjustment Index and Participation Index. Items are scored on a 5-point Likert scale, with lower scores indicating higher levels of functioning.
Time frame: baseline, 5 weeks, 10 weeks, 20 weeks
change in the PTSD Checklist (PCL)
20-item self-report measure assessing the distress associated with PTSD symptoms. The higher the score, the worse the symptoms.
Time frame: baseline, 5 weeks, 10 weeks, 20 weeks
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delivered with the Magventure MagProX100 with MagOption stimulator and Magpro Cool Coil B65 A/P. The Magpro Cool Coil B65 A/P can be switched to active or placebo (A/P).