Evaluation of Novel Lung Function Parameters in Patients With Bronchial Asthma

N/ACompletedNCT03820427

Universitätsmedizin Mannheim147 enrolled

Overview

Current guideline-based criteria defining bronchial asthma do not always meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used functional diagnostic approaches for the detection and therapeutic monitoring of patients with asthma.

Study Type

OBSERVATIONAL

Enrollment

147

Conditions

Bronchial Asthma Pulmonary Healthy Controls

Interventions

impulse oscillometryDIAGNOSTIC_TEST

impulse oscillometry

multiple breath washout testDIAGNOSTIC_TEST

multiple breath washout test

body plethysmographyDIAGNOSTIC_TEST

body plethysmography

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * known or suspected bronchial asthma * known or suspected obstructive ventilation disorder * pulmonary healthy controls Exclusion Criteria: * pregnancy * inability to participate

Outcomes

Primary Outcomes

Global ventilation heterogeneity

lung clearance index (LCI) derived from sulphur hexafluoride multiple breath washout

Time frame: 30 minutes

Local ventilation heterogeneity

Sacin, Scond (Phase III slopes) derived from sulphur hexafluoride multiple breath washout

Time frame: 30 minutes

Data from ClinicalTrials.gov

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