Safety, Tolerability, Pharmacokinetics and Efficacy of SCT-I10A in Patients With Advanced Solid Tumors or Lymphoma

Inclusion Criteria: * Able to provide written informed consent before screening； * Males or females. Aged 18 to 75 years old; * Life expectancy≥12 weeks before starting treatment (clinical assessment); * With an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1; * Histologically or cytologically confirmed advanced solid tumor or lymphoma; * Advanced solid tumor or lymphoma with standard treatment failed or no effective therapy; * According to RECIST 1.1 or Lugano 2014 criteria, patients must have at least one measurable lesion that can be accurately assessed; * Adequate organ and bone marrow function as defined below: Absolute neutrophil count (ANC) greater than/equal to 1.5×l09/L; Platelets greater than/equal to 75×109/L; Hemoglobin greater than/equal to 80g/L; Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) less than/equal to 2.5 times ULN, or less than/equal to 5 times ULN if known liver metastases; Total bilirubin less than/equal to 1.5 times ULN; Serum creatinine less than/equal to 1.5 times ULN or Ccr\>50ml/min; Thyroid stimulating hormone (TSH) hormone levels less than/equal to ULN. Exclusion Criteria: * Patients who are allergic to analogue of SCT-I10A and/or its inactive ingredients; * Patients have been treated with anti-PD-L1 and anti-PD-1 antibody; * Patients are currently enrolled in other research devices or in research drugs, or less than 4 weeks from other research drugs or devices; * Within 4 weeks prior to the first dose of study drug, patients have received anti-tumor drugs (such as chemotherapy, endocrine therapy, targeted therapy, immune therapy, tumor embolization). Within 6 weeks prior to the first dose of study drug, patients have been treated with biological products, nitrosourea or mitomycin C; * Within 2 weeks prior to the first dose of study drug, patients have received corticosteroids or other immunosuppressive agents; * Within 4 weeks prior to the first dose of study drug, patients have received live attenuated vaccine (LAV), or who planned to use LAV during the study period; * Within 4 weeks prior to the first dose of study drug, patients have received major surgery, or had wounds, ulcers or fractures that haven't healed; * Prior to the first dose of study drug, patients had toxicity due to previous anti-tumor treatment, which hasn't return to Grade 0-1 according to the NCI CTCAEv4.03; * Patient with cerebrospinal meningitis metastasis or central nervous system metastasis with untreated or uncontrolled with other treatment; * Patients with an active, known or suspected autoimmune disease or a history of autoimmune disease; * Patients with a history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation; * Within 6 months prior to study, patients had uncontrolled concurrent diseases, including but not limited to acute myocardial infarction, unstable angina pectoris, stroke, or transient ischemic attack, congestive heart failure (NYHA, greater than II), left ventricular ejection fraction (LVEF) \<50%, and with related heart disease. Patients with chronic or acute disease, psychological or psychiatric disorders, laboratory abnormalities which may affect subject compliance and outcomes in this clinical study; * Patients with HIV, active hepatitis B (HBV DNA≥104 copies/ml) or active hepatitis C (HCV RNA≥103 copies/ml), etc.; * Patients who have interstitial lung disease, such as interstitial pneumonia, pulmonary fibrosis, or CT or MRI reminder ILD. * Patients with clinical symptoms, required clinical intervention or stable time less than 4 weeks of serous cavity effusion (such as pleural effusion and ascites); * Patients with other primary malignancies; * Pregnant or lactating women; * Patients who were not willing to accept effective contraceptive measures during treatment and within 6 months after treatment; * Subjects who are considered not suitable for the study by investigator.