Dual beam Doppler Fourier-domain Optical coherence tomography (DOCT) is a noninvasive technique to quantify total retinal blood flow. To enable further development of this technique it is essential to assess short- and long-term reproducibility of DOCT blood flow measurements.
In the present study, total retinal blood flow will be measured with DOCT at multiple time points to gain information of short- and long-term reproducibility. In addition, provocation with flickering light will be performed, which is known to lead to vasodilatation and an increase in retinal blood flow in healthy subjects. Vessel diameters will also be measured using the Dynamic Vessel Analyzer (DVA).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
20
Retinal blood flow will be assessed using DOCT.
Retinal vessel diameters and oxygen saturation will be measured with the DVA device.
Retinal morphology will be imaged using OCT.
Medical University of Vienna, Department of Clinical Pharmacology
Vienna, State of Vienna, Austria
RECRUITINGRetinal blood-flow variation over time
as measured using DOCT
Time frame: 14 +/- 3 days
Flicker induced blood flow alterations
as measured using DOCT
Time frame: 14 +/- 3 days
Flicker induced vasodilatation and hyperemia
as measured using DOCT and DVA
Time frame: 14 +/- 3 days
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