Exercise Training in Individuals With Coronary Artery Disease

University Medical Centre Ljubljana115 enrolled

Overview

In this controlled trial, patients referred to post-myocardial infarction cardiac rehabilitation will be randomized to either interval or continuous training.

The trial would i) compare the acute effects of each exercise type on selected cardiovascular indicators; ii) compare the chronic effects of each exercise type on selected cardiovascular indicators; iii) provide information on the association between acute and chronic effects of each exercise type; iv) provide insight into possible mechanisms of effectiveness of each exercise type; v) identify the most safe and effective exercise type for patients with coronary artery disease.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

115

Conditions

Coronary Artery Disease Myocardial Infarction

Interventions

Exercise trainingOTHER

Patients to be randomized to the 'interval training group' or 'continuous training group' will undergo exercise training sessions with different intensity levels.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * myocardium infarction 120 days prior to cardiac rehabilitation Exclusion Criteria: * contraindications for exercise training, * uncontrolled dysrhythmias, * uncontrolled heart failure (New York Heart Association (NYHA) stage IV), * intellectual development disorder, * pregnancy.

Locations (1)

University Medical Centre Ljubljana

Ljubljana, Slovenia

Outcomes

Primary Outcomes

Change of flow-mediated dilatation of the brachial artery, measured in %

Time frame: 3 months

Secondary Outcomes

Change of the arterial stiffness coefficient

Time frame: 3 months

Change of maximal oxygen uptake during exercise, measured in ml/kg/min

Time frame: 3 months

Change of the heart rate variability

Time frame: 3 months

Change of the heart rate recovery

Time frame: 3 months

Change in health-related quality of life using SF-36 questionnaire, measured in points

It is a self-administered questionnaire comprising 36 items measuring eight dimensions and two subscales (physical and mental)

Time frame: 3 months

Change in IL-6, IL-8, IL-10, TNF-alpha and NT-proBNP levels, measured in ng/l

Time frame: 3 months

Change in osteopontin and D-dimer levels, measured in microg/l

Time frame: 3 months

Change in selectin and hsCRP, measured in mg/l

Time frame: 3 months

Change in hsTnI, CK MB, endocan, sST2, galectin-3, NGAL, CD40 ligand and BDNF, measured in ng/l

Time frame: 3 months

Change in copeptin levels, measured in pmol/l

Data from ClinicalTrials.gov

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