This study aimed to investigate the effect of Glucocorticoid combined with vitamin C and vitamin B1 versus hydrocortisone alone on microcirculation in septic shock patients.
This prospective, double-blind, randomized, controlled trial enrolled septic shock patients admitted to the intensive care unite of a tertiary teaching hospital. We randomly assigned the enrolled patients to the treatment group (hydrocortisone combined with vitamin C and vitamin B1 added to standard care) and the control group (hydrocortisone alone added to standard care) in a 1:1 ratio. The primary outcome was perfusion vascular density (PVD) at 24 hours after treatment. We used the sublingual microcirculation imaging system to monitor PVD. We further validated the primary outcome by observing differences in renal perfusion monitored by renal contrast-enhanced ultrasound (CEUS) between the treatment group and the control group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
22
Glucocorticoid combination therapy is defined as the combination of hydrocortisone, vitamin C, and vitamin B1.
The glucocorticoid group was defined as the use of hydrocortisone alone.
Nanjing Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China
Perfused vessel density (PVD)
Determinant of capillary diffusive capacity
Time frame: 24 hours after treatment
proportion of perfusion vessels
sublingual microcirculation parameter
Time frame: 24 hours after treatment
total vascular density
sublingual microcirculation parameter
Time frame: 24 hours after treatment
microvascular flow index
sublingual microcirculation parameter
Time frame: 24 hours after treatment
renal contrast-enhanced ultrasound parameters
renal perfusion
Time frame: 24 hours after treatment
lactate
Tissue perfusion parameter
Time frame: 24 hours after treatment
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