Intra-arterial Infusion Chemotherapy Combined With Sodium Bicarbonate for Unresectable Gastric Cancer

Inclusion Criteria: 1. Patients aged 18 to 75 years; 2. Ultrasound gastroscopy or imaging (CT) can diagnose potentially unresectable gastric cancer (T4a-bN2-3M0) with indications of neoadjuvant chemotherapy or transformation therapy; 3. Pathological diagnosis of gastric cancer; 4. No contraindication of chemotherapy; 5. Patients who did not undergo chemotherapy or were diagnosed for the first time. Exclusion Criteria: 1. Those who fail to comply with the requirements of the trial, obviously violate this regimen, or change to other regimens in the course of treatment; 2. The life expectancy of patients with extensive systemic metastasis is less than 3 months; 3. Leukocyte count is less than 2\*109/L and platelet count is less than 75\*10\^9/L; 4. Severe heart, liver and kidney diseases, unable to tolerate chemotherapy; 5. Patients without gastric cancer complications such as massive gastrointestinal bleeding and perforation need to be treated in emergency department; 6. Patients with distant metastasis (excluding group 16 lymph node metastasis); 7. Patients with other tumors, with a history of malignant tumors (excluding early primary cancers); 8. The patient himself asked to withdraw from the trial; 9. Researchers believe that patients are not suitable for this study.