Staccato Apomorphine Single and Multi Dose PK

Inclusion Criteria: * Healthy adult males and females between 18 and 60 years of age, inclusive at the time of signing the informed consent document. * Body weight ≥ 50 kg and BMI within the range of 18 to 32 kg/m2. * Willing and able to be confined at the clinical research center for the study period and adhere to overall study visit schedule, procedures and other protocol requirements. * Understand and voluntarily sign an informed consent document prior to any study related assessments/procedures being conducted. Exclusion Criteria: * Any significant medical condition, psychiatric illness or history of depression that could, in the investigator's opinion, compromise the subject's safety or interfere with the completion of this protocol. * History of clinically significant central nervous system, cardiac, pulmonary, metabolic, renal, hepatic, or gastrointestinal conditions including gastric bypass or other weight loss surgical procedure; or history of such conditions that, in the opinion of the investigator, may place the subject at an unacceptable risk as a participant in this trial. * Use of non-prescription medications within 5 days prior to the first dose of study drug. * Use of medication that is inhibitor or inducer of CYP450-3A4/5 within 3 days of dosing. * Consumption of grapefruit, grapefruit juice, star fruit, oranges, orange juice, Seville oranges, within 3 days prior to administration of study drug.