Observational Study to Investigate the Effects of Training on the Administration of Cardioplexol™

Inclusion Criteria: * Male or female patients between 18 and 80 years of age; * The patient's pre-operative evaluation indicates the need for a primary elective cardiac coronary artery bypass graft (CABG) operation and/or a cardiac valve repair/replacement; * The operation can be carried out via a full sternotomy, under cardiac arrest and under the assistance of a heart lung machine; * Patients who provide signed written informed consent. Exclusion Criteria: * Pre-operative EF of less than 30%; * Pre-operative IABP; * Pre-operative catecholamine support; * History of myocardial infarction within less than 7 days; * Previous history of cardiac surgery, including the implantation of a pace maker or an ICD; * Active myocarditis and/or endocarditis; * Aortic valve insufficiency severity grade more than 1; * Under dialysis; * Pre-operative serum creatinine value of more than 2.0 mg/dl; * Known hematologic disorder; * Treatment with anti-vitamin K; * History of HIT; * Participating in a concomitant research study of an investigational product; * Pregnant or lactating; * Intravenous drug user, alcohol abuser, prisoner, institutionalized, or is unable to give informed consent