This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.
This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups. 15 different Groups are analysed: control Group, 5000ft Group, 8000 ft Group, 10000ft Group and 15000ft Group - all for 15, 30, and 60 minutes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
250
hypoxia
University Hospital of Cologne
Cologne, North Rhine-Westphalia, Germany
Protein Expression before hypoxia
proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics
Time frame: Measurement immediately 1 minute before of hypoxia/experiment
Protein Expression after hypoxia
proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics
Time frame: Measurement immediately and at termination (i.e., 1 minute after) of hypoxia/experiment
Emotional assessment tears
Emotional tears test
Time frame: Measurement starts immediately with hypoxia in the pressure chamber. duration 10 minutes
Emotional assessment
Emotional stroop test; Williams, J. M. G., Mathews, A., \& MacLeod, C. (1996). The emotional Stroop task and psychopathology. Psychological Bulletin, 120, 3-24.
Time frame: Measurement in the pressure chamber after tears test (i.e. 10 minutes after start). duration 10 minutes
Emotional assessment mood
Emotional mood test, POMS mood score. Shukitt-Hale, B., Banderet, L.E., \& Lieberman, H.R. (1998). Elevation-dependent symptom, mood, and performance changes produced by exposure to hypobaric hypoxia, The International Journal of Aviation Psychology, 8, 319-334,
Time frame: Measurement in the pressure chamber after stroop test (i.e. 20 minutes after start). duration 10 minutes
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