ECigs, Inflammation and Oxidative Stress

University of California, Los Angeles148 enrolled

Overview

Randomized controlled trial of acute use of electronic cigarette effect on oxidative stress and inflammation.

Participants will have an acute e-cig exposure on 2 occasions 1) e-cigarette 2) sham e-cig (empty e-cig) control. Blood will be collected before and after E-cig use and analyzed for biomarkers of inflammation and oxidative stress.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

148

Conditions

E-cigarettes, Oxidative Stress, Inflammation

Interventions

e-cigaretteOTHER

use e-cig for 30 minutes

empty (-cigarette sham control)OTHER

use empty e-cig (sham control)

Eligibility

Sex: ALLMin age: 21 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy Exclusion Criteria: * Cardiac disease Respiratory disease Diabetes

Locations (1)

UCLA

Los Angeles, California, United States

Outcomes

Primary Outcomes

Cellular Reactive Oxygen Species, units = % fluorescence

cellular oxidative stress, including cytoplasmic and mitochondrial oxidative stress, in viable cells

Time frame: within 4 hours of E-cig use

Secondary Outcomes

CD 14+ Monocyte, units = % of total cells

CD 14+ Monocyte, % of total cells will be measured with antibodies and stable dye

Time frame: within 4 hours of e-cig use

Data from ClinicalTrials.gov

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