Until now there is no medical treatment and/or intervention that can slow, stop or reverse the underlying neurodegenerative of Alzheimer's disease (AD). The goal of this study is to demonstrate "Oleocanthal rich-extra-virgin olive oil (EVOO) consumption stops or delay mild cognitive impairment conversion to AD by restoring the blood-brain barrier (BBB) function in humans". Specific Aims: 1. Evaluate effect of EVOO on the brain function by functional MRI (fMRI) imaging, and BBB function by dynamic contrast-enhanced MRI (DCE-MRI). 2. Evaluate effect of EVOO on cognitive function and on selected biomarkers
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
25
Extra-virgin olive oil that is rich with oleocanthal and other phenols.
Olive oil low in oleocanthal and other phenols.
Auburn University
Auburn, Alabama, United States
Effect of olive oil on the BBB intactness
Will be evaluated by DCE-MRI
Time frame: 6 months
Effect of olive oil on the brain activity
Will be evaluated by fMRI
Time frame: 6 months
Cognitive function
A battery of cognitive tasks to assess memory
Time frame: 6 months
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