The conventional hypoxic challenge test might not predict 'fitness-to-fly' equally well in all patients. Patients at risk of hypercapnia with supplemental oxygen are not well studied. Th investigators will study children who have either neuromuscular weakness or central hypoventilation and who require nocturnal or intermittent daytime ventilator support. The study also aims to assess feasibility of a randomised controlled trial (RCT) comparing the standard hypoxic standard test to a modified test designed to better suit children with type two respiratory failure.
This study will assess feasibility of pulse oximetry (SpO2), end tidal carbon dioxide (ETCO2) and transcutaneous carbon dioxide partial pressure (TcCO2) measurement during a modified Hypoxic challenge test (HCT) in 12 children with neuromuscular weakness and 12 with central hypoventilation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
20
Physiological response to 15% ambient oxygen monitored.
Great Ormond Street Hospital for Children NHS Foundation Trust
London, United Kingdom
proof of concept outcome 1
number of children/infants with SpO2 \<90/85%
Time frame: during hypoxic challenge test
proof of concept outcome 2
number of children with \>15 mmHg rise in TcCO2/EtCO2
Time frame: during hypoxic challenge test
Feasibility outcome 1: recruitment rate
recruitment rate
Time frame: one year
Feasibility outcome 2: protocol completion rate
protocol completion rate
Time frame: one year
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