The Clinical Value of Chromoendoscopy as Surveillance Strategy for Dysplasia Detection in Ulcerative Colitis

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)210 enrolled

Overview

A recent multicentre randomised controlled trial compared autofluorescence imaging (AFI) with CE for dysplasia detection in colonoscopy surveillance of patients with longstanding UC (FIND-UC). In this study, CE detected significantly more dysplastic lesions per patient compared with AFI. It is unclear whether this increased dysplasia detection also translates to a reduction of dysplasia at follow-up colonoscopy. The aim of this pre-specified study is therefore to prospectively determine whether there is a difference in dysplasia detection at follow-up colonoscopy between UC patients who were randomized to AFI or CE at index colonoscopy for the FIND-UC trial.

Study Type

OBSERVATIONAL

Enrollment

210

Conditions

Ulcerative Colitis Chromoendoscopy

Interventions

Surveillance colonoscopy with chromoendoscopyPROCEDURE

Surveillance colonoscopy with chromoendoscopy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Patients are eligible for inclusion in this study when they meet the following criteria: Inclusion criteria In order to be eligible to participate in this study, a subject must meet all of the following criteria: \- Patients that where included in the previous FIND-UC trial Exclusion criteria A potential subject who meets any of the following criteria will be excluded from participation in this study: * Patients who not receive their surveillance colonoscopy with CE * Patients who not undergo their surveillance colonoscopy within 3 months of the surveillance recommendations Withdrawal of individual subjects A patient will be excluded from the study if any of the following events occur: * Withdrawal of informed consent * The patient requests to be discontinued from the study * The bowel preparation is scored as Boston Bowel Preparation Scale \<6 * Incomplete colonoscopy because the endoscopist is unable to intubate the cecum during the colonoscopy * The Mayo-score \> 1 in at least in one of the bowel segments

Outcomes

Primary Outcomes

the proportion of patients in which at least one histological proven dysplastic lesions was detected at follow-up colonoscopy.