This study was the efficacy and safety of Sesame oil cake extract on improvement of Cognitive Function
This study was a 12 weeks, randomized, double-blind, placebo-controlled human trial to evaluate. 70 subjects were participated in Sesame Oil Cake Extract or placebo group. To evaluate the changes of the evaluation items when Sesame Oil Cake Extract was taken three times a day compared with placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
70
Sesame Oil Cake Extract 1.5 g/day for 12 weeks.
placebo for 12 weeks.
Department of Psychiatry, Chonbuk National University Hospital
Jeonju, South Korea
Changes of Visual learning test
Visual learning test was measured in baseline and 12 weeks.
Time frame: 12 weeks
Changes of Visual working memory test
Visual working memory test was measured in baseline and 12 weeks.
Time frame: 12 weeks
Changes of Verbal learning test
Verbal learning test was measured in baseline and 12 weeks.
Time frame: 12 weeks
Changes of the Montreal Cognitive Assessment(MoCA-K)
The cognitive function evaluation using the Montreal Cognitive Assessment(MoCA-K) is a total of 8 items, and evaluates cognitive functions such as time / execution power, vocabulary, memory, attention, sentence, abstraction, delayed recall, and orientation. Time / execution power's total score is 5 points, vocabulary's total score is 3 points, attention's total score is 3 points, sentence's total score is 3 points, abstraction's total score is 2 points, delayed recall's total score is 5 points, orientation's total score is 6 points. It takes about 10 minutes to complete, and the total score is 30 points and total score make sum score. A score of 23 points or more is regarded as normal. If you have less than 6 years of education, add 1 point. It takes about 10 minutes to complete, and the score is 30 points. A score of 23 points or more is regarded as normal. If you have less than 6 years of education, add 1 point.
Time frame: 12 weeks
Changes of beta-amyloid
Beta-amyloid(pg/mL) was measured in baseline and 12 weeks.
Time frame: 12 weeks
Changes of Oxidation index(8-OHdG)
Oxidation index(8-OHdG)(ng/mL) was measured in baseline and 12 weeks.
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Time frame: 12 weeks