Glucosamine and Chondroitin in Preventing Inflammation in Overweight Patients

Inclusion Criteria: -Individuals from the Greater Seattle area who are overweight (body mass index \[BMI\] of 25-32.5 kg/m\^2) Exclusion Criteria: * Chronic medical illness, history of gastrointestinal, hepatic, or renal disorders, or inflammatory conditions (including autoimmune and inflammatory diseases) * Pregnancy or lactation * Currently on a weight-loss diet * BMI (body mass index) \< 25 or \> 32.5 kg/m\^2 * Alcohol intake of greater than 2 drinks/day (2 drinks being equivalent to 720 ml beer, 240 ml wine or 90 ml spirits) * Current use of prescription or over-the-counter medications other than oral contraceptives and hormone secreting intrauterine device (IUD)s, multivitamin pills or infrequent use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), or use of aspirin or NSAIDs more than 2 days per week * Abnormal renal, liver or metabolic test * Inability to swallow pills * Known allergy to shellfish * Not willing to take pills made from shellfish or animal sources * Intention to relocate out of study area within next 2 months * Any antibiotic use in the past 6 months