Novum Vitrium® Cervical Cage in Anterior Cervical Discectomy and Fusion

Inclusion Criteria: 1. Symptomatic cervical disc disease (SCDD) in the one vertebral level between C3/C4 to C7/T1, defined as neck or arm (radicular) pain, or functional or neurological deficit and correlated with radiculopathy or myelopathy or radiographic confirmation (by CT, MRI, x-ray, etc.) of any of the following: * Herniated nucleus pulposus; * Spondylosis (defined by the presence of osteophytes); or * Loss of disc height. 2. Requires only one cervical vertebral level to be surgically treated, confirmed radiologically by Xray, CT, or MRI and correlated with neurologic examination prior to enrollment; 3. Age between 22 and 70 years (inclusive); 4. Skeletally mature patients; 5. Failed at least 6 weeks of conservative treatment (e.g. medication, physical therapy), or exhibit progressive symptoms or signs of spinal cord/nerve root compression with continued non-operative care; 6. Neck Disability Index (NDI) Questionnaire score of at least 30 (on a scale from 0 to 100); 7. Able to read and Understand all documents used in this study, including the Informed Consent and patient-reported outcome questionnaires; 8. Understand and read English at elementary level; 9. Patient must understand and sign the Informed Consent document that has been approved by the Ethics committee, Institutional review Board and the FDA. Exclusion Criteria: 1. More than one vertebral level requiring treatment, confirmed radiologically by X-ray, CT, or MRI 2. Cervical instability; 3. Prior fusion surgery at any cervical vertebral level; 4. Prior surgery at the level to be treated with the exception of surgery that does not require the use of hardware and/or the treatment of facet disease; 5. Severe facet disease; 6. Clinically compromised vertebral bodies at the affected level(s) due to current or past trauma 7. Neck or arm pain of unknown etiology; 8. Osteoporosis, osteopenia, Paget's disease, osteomalacia or any other metabolic bone disease; a. Osteoporosis is defined as history of fragility fracture and Dexa (DXA) T-score \< -2.5 or QCT T-score \< 80mg/cubic cm. History of a fragility fracture requires that a DXA scan or QCT scan is completed 9. Pregnant or interested in becoming pregnant in the next 2 years; 10. Active systemic or local infection; 11. History of severe allergy or anaphylaxis especially to titanium, polyethylene, cobalt, chromium or molybdenum; 12. Taking medications or any drug known to potentially interfere with bone/soft tissue healing (e.g., steroids, bisphosphonates); 13. Rheumatoid arthritis or another autoimmune disease that affects musculoskeletal system; 14. Acquired immune deficiency syndrome (AIDS) or an AIDS-related complex; 15. Active malignancy or history of invasive malignancy within the last five years, except for superficial basal cell carcinoma or squamous cell carcinoma of the skin that has been definitely treated; patients with carcinoma in situ of the uterine cervix treated definitely more than 1 year prior to enrollment may enter the study; 16. Neuromuscular disorders such as muscular dystrophy, spinal muscular atrophy, and amyotrophic lateral sclerosis; 17. Pre-existent neurologic or mental disorder which would preclude accurate evaluation and followup (i.e. Alzheimer's disease, Parkinson's disease, unstable psychiatric disorder with hallucinations and/or delusions or schizophrenia); 18. Substance use disorder categorized as moderate to severe as defined in DSM-V; 19. Mental/Psychiatric disorder as defined in DSM-V; 20. Alcohol abuse disorder categorized as moderate to severe as defined in DSM-V; 21. Current Smokers; 22. Use of bone growth stimulator in the region of the cervical spine within the past 30 days; 23. Participation in other investigational device or drug clinical trials within 30 days of surgery; 24. Prisoners; 25. Morbid obesity, defined as body mass index ("BMI") \> 40; 26. Type 1 diabetes mellitus requiring daily insulin therapy unless there is documentation of a recent A1c (within 6 months) of less than 7.1 or Type 2 diabetes where the clinical presentation precludes the patient from having surgery; 27. Involved in litigation related to the spine; 28. On workers compensation