Evaluation of Soybean Peptides Product on Regulation of Blood Pressure Effect in Humans

Chung Shan Medical University30 enrolled

Overview

This is the report to assess supplementation with soybean peptides on blood pressure among people with mild hypertension. Overall, soybean peptide consumption for 8 weeks could successfully reduce mean diastolic and systolic BP through the suppression of Angiotensin-converting enzyme (ACE) linked to downstream suppression of angiotensin II formation, which further decreases the sympathetic outflow that leads to hypertension.

This is the report to assess supplementation with soybean peptides on blood pressure among people with mild hypertension. Thirty subjects with systolic blood pressure (SBP) between 120 and 159 mm Hg and/or diastolic blood pressure (DBP) between 80 and 99 mm Hg were randomized to ingest 2 bags of soybean peptides or placebo per day for 8 weeks of a stage. Anthropometric measurements (blood pressure, body weight, body fat) and blood biochemical markers including fasting blood glucose (FBG), albumin, total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, creatinine (Cr), blood urea nitrogen (BUN), AST, ALT) were examined every four weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Hypertension

Interventions

Soybean peptidesDIETARY_SUPPLEMENT

Subjects receive two bags soybean peptides per day for 8 weeks of a stage. Anthropometric measurements such as blood pressure (systolic blood pressure \[SBP\] and diastolic blood pressure \[DBP\]), body weight, body fat, waistline, hipline and blood biochemical parameters including FBG, albumin, TC, TG, HDL-C, LDL-C, Cr, BUN, AST and ALT were measured every four weeks.

PlaceboDIETARY_SUPPLEMENT

Subjects receive two bags of starch placebo of similar appearance per day for 8 weeks of a stage. Anthropometric measurements such as blood pressure (systolic blood pressure \[SBP\] and diastolic blood pressure \[DBP\]), body weight, body fat, waistline, hipline, and blood biochemical parameters including FBG, albumin, TC, TG, HDL-C, LDL-C, Cr, BUN, AST, and ALT were measured every four weeks.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Eligible subjects were untreated hypertensive men or women aged between 20 and 80 years old with SBP between 120 and 159 mmHg and/or DBP between 80 and 99 mmHg as measured in a sitting position Exclusion Criteria: * Subjects were excluded if they had a history of major cardiovascular disease or severe liver dysfunction; * Diastolic blood pressure ≥ 100 mmHg or Systolic blood pressure ≥ 160 mmHg; * Alcoholic; * US-controlled diabetics; * Stoke in past one year; * Mental diseases or melancholia; * Pregnancy or breast-feeding a child; * Renal dysfunction; * Allergic to Soybean peptides.

Locations (1)

Chung Shan Medical University

Taichung, Taiwan

Outcomes

Primary Outcomes

The soy bean peptides anti-hypertensive measure blood pressure (SBP and DBP)

values chang of systolbbic and diastolic BPs between before to after 8 weeks

Time frame: 8 weeks

Data from ClinicalTrials.gov

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