Following successful CTO PCI, a multitude of physiological and anatomical changes take place. Contemporary techniques such as dissection/re-entry or lumen-lumen wiring may influence the immediate and longer term follow up of these features. It is not known whether changes in this level of physiology and anatomy in the context of CTO vessels correlate with each other, or with quality of life and exercise capacity. This study aims to take physiological measurements of absolute coronary flow, resistance and pressure and intra-coronary imaging immediately after successful CTO PCI. The investigators will relate these to each other and to the method of revascularisation, comparing changes in these groups at three months follow up. QoL measurements, and exercise testing will be carried out to see if there is a relationship between physiological and anatomical changes with exercise capacity and quality of life. Results from this study could shed light on optimisation of CTO PCI procedural and clinical outcomes.
Following successful chronic total occlusion (CTO) percutaneous coronary intervention (PCI), a multitude of physiological and anatomical changes take place. Contemporary techniques such as dissection/re-entry or lumen-lumen wiring may influence the immediate and longer term follow up of these features. It is not known whether changes in this level of physiology and anatomy in the context of CTO vessels correlate with each other, or with quality of life and exercise capacity. This study aims to take physiological measurements of absolute coronary flow, resistance and pressure and intra-coronary imaging immediately after successful CTO PCI. The investigators will relate these to each other and to the method of revascularisation, comparing changes in these groups at three months follow up. Quality of life measurements, and exercise testing will be carried out to see if there is a relationship between physiological and anatomical changes with exercise capacity and quality of life. Results from this study could shed light on optimisation of CTO PCI procedural and clinical outcomes.
Study Type
OBSERVATIONAL
Enrollment
40
The Essex Cardiothoracic Centre
Basildon, Essex, United Kingdom
Change in coronary flow
change in coronary flow at baseline and follow up
Time frame: 3 months
Change in coronary resistance
change in coronary absolute resistance at baseline and follow up
Time frame: 3 months
Change in coronary anatomy
To identify intracoronary anatomical features between baseline and follow up.
Time frame: 3 months
Change in exercise work load
Change in exercise work measured in METS (metabolic equivalents).
Time frame: 3 months
Change in quality of life
change in quality measured by the validated Seattle angina seven question questionnaire from baseline to follow up. This is a scale based on 7 questions giving scores of 0-100 on physical limitation, angina, and quality of life, with the average of these scores giving a mean value also ranging from 0-100 of the overall summary score.
Time frame: 3 months
Change in coronary pressure measurements
change in fractional flow reserve (FFR) at baseline and follow up
Time frame: 3 months
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