The Bean Study will examine the effects of consuming two daily amounts of canned beans of multiple varieties on fasting serum cholesterol profile in adults with elevated LDL cholesterol.
The Bean Study (TBS) is a a multi-centre, randomized, crossover design study which will examine the effects of consuming two daily amounts of canned beans of multiple varieties on fasting serum cholesterol profile in adults with elevated LDL cholesterol. Participants will consume daily amounts of 1 cup canned beans, ½ cup of canned beans and 1 cup of white rice for 4 weeks each, separated by minimum 4-week washout periods. At the start and end of each 4-week treatment period, fasting blood samples will be collected and analyzed for lipids, glucose insulin and short chain fatty acids (SCFAs). Fecal samples will also be collected and analyzed for SCFA, bile acids and gut microbiota. Body weight and BMI will be also be measured at the start and end as well as mid-way of each treatment period. Finally 3-day food records will be completed mid-way during each treatment period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
73
Daily rotation of different varieties of canned beans including black, navy, pinto, red kidney and white kidney
Minute Rice Long Grain White Rice
Human Nutraceutical Research Unit
Guelph, Ontario, Canada
Glycemic Index Laboratories, Inc
Toronto, Ontario, Canada
Fasting serum LDL cholesterol
Fasting serum LDL cholesterol will be compared among treatments at study day 29 using ANCOVA and including study day 1 as a covariate
Time frame: 4 weeks (28 days)
Fasting serum total cholesterol, HDL cholesterol and triglycerides
Time frame: 4 weeks (28 days)
Fasting serum glucose and insulin and HOMA-IR
Fasting glucose and insulin
Time frame: 4 weeks (28 days)
Fasting serum and fecal short chain fatty acids
Time frame: 4 weeks (28 days)
Fecal bile acids
Time frame: 4 weeks (28 days)
Gut Microbiota
Time frame: 4 weeks (28 days)
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